                     SEQUENCE LISTING			PCT/EP 2015/060402
							17-08-2015	
<110>  F. Hoffmann la Roche AG
 
<120>  OLIGOMERS AND OLIGOMER CONJUGATES TARGETING HBV

<130>  32180

<150>  GB1408623.5
<151>  2014-05-15

<160>  862   

<170>  PatentIn version 3.5

<210>  1
<211>  746
<212>  DNA
<213>  Hepatitis B virus

<400>  1
aacccccact ggctggggct tggtcatggg ccatcagcgc gtgcgtggaa ccttttcggc       60

tcctctgccg atccatactg cggaactcct agccgcttgt tttgctcgca gcaggtctgg      120

agcaaacatt atcgggactg ataactctgt tgtcctctcc cgcaaatata catcgtatcc      180

atggctgcta ggctgtgctg ccaactggat cctgcgcggg acgtcctttg tttacgtccc      240

gtcggcgctg aatcctgcgg acgacccttc tcggggtcgc ttgggactct ctcgtcccct      300

tctccgtctg ccgttccgac cgaccacggg gcgcacctct ctttacgcgg actccccgtc      360

tgtgccttct catctgccgg accgtgtgca cttcgcttca cctctgcacg tcgcatggag      420

accaccgtga acgcccaccg aatgttgccc aaggtcttac ataagaggac tcttggactc      480

tctgcaatgt caacgaccga ccttgaggca tacttcaaag actgtttgtt taaagactgg      540

gaggagttgg gggaggagat tagattaaag gtctttgtac taggaggctg taggcataaa      600

ttggtctgcg caccagcacc atgcaacttt ttcacctctg cctaatcatc tcttgttcat      660

gtcctactgt tcaagcctcc aagctgtgcc ttgggtggct ttggggcatg gacatcgacc      720

cttataaaga atttggagct actgtg                                           746


<210>  2
<211>  1969
<212>  DNA
<213>  Hepatitis B virus

<400>  2
cactcatcct caggccatgc agtggaattc cacaaccttt caccaaactc tgcaagatcc       60

cagagtgaga ggcctgtatt tccctgctgg tggctccagt tcaggagcag taaaccctgt      120

tccgactact gcctctccct tatcgtcaat cttctcgagg attggggacc ctgcgctgaa      180

catggagaac atcacatcag gattcctagg accccttctc gtgttacagg cggggttttt      240

cttgttgaca agaatcctca caataccgca gagtctagac tcgtggtgga cttctctcaa      300

ttttctaggg ggaactaccg tgtgtcttgg ccaaaattcg cagtccccaa cctccaatca      360

ctcaccaacc tcctgtcctc caacttgtcc tggttatcgc tggatgtgtc tgcggcgttt      420

tatcatcttc ctcttcatcc tgctgctatg cctcatcttc ttgttggttc ttctggacta      480

tcaaggtatg ttgcccgttt gtcctctaat tccaggatcc tcaaccacca gcacgggacc      540

atgccgaacc tgcatgacta ctgctcaagg aacctctatg tatccctcct gttgctgtac      600

caaaccttcg gacggaaatt gcacctgtat tcccatccca tcatcctggg ctttcggaaa      660

attcctatgg gagtgggcct cagcccgttt ctcctggctc agtttactag tgccatttgt      720

tcagtggttc gtagggcttt cccccactgt ttggctttca gttatatgga tgatgtggta      780

ttgggggcca agtctgtaca gcatcttgag tcccttttta ccgctgttac caattttctt      840

ttgtctttgg gtatacattt aaaccctaac aaaacaaaga gatggggtta ctctctgaat      900

tttatgggtt atgtcattgg aagttatggg tccttgccac aagaacacat catacaaaaa      960

atcaaagaat gttttagaaa acttcctatt aacaggccta ttgattggaa agtatgtcaa     1020

cgaattgtgg gtcttttggg ttttgctgcc ccatttacac aatgtggtta tcctgcgtta     1080

atgcccttgt atgcatgtat tcaatctaag caggctttca ctttctcgcc aacttacaag     1140

gcctttctgt gtaaacaata cctgaacctt taccccgttg cccggcaacg gccaggtctg     1200

tgccaagtgt ttgctgacgc aacccccact ggctggggct tggtcatggg ccatcagcgc     1260

gtgcgtggaa ccttttcggc tcctctgccg atccatactg cggaactcct agccgcttgt     1320

tttgctcgca gcaggtctgg agcaaacatt atcgggactg ataactctgt tgtcctctcc     1380

cgcaaatata catcgtatcc atggctgcta ggctgtgctg ccaactggat cctgcgcggg     1440

acgtcctttg tttacgtccc gtcggcgctg aatcctgcgg acgacccttc tcggggtcgc     1500

ttgggactct ctcgtcccct tctccgtctg ccgttccgac cgaccacggg gcgcacctct     1560

ctttacgcgg actccccgtc tgtgccttct catctgccgg accgtgtgca cttcgcttca     1620

cctctgcacg tcgcatggag accaccgtga acgcccaccg aatgttgccc aaggtcttac     1680

ataagaggac tcttggactc tctgcaatgt caacgaccga ccttgaggca tacttcaaag     1740

actgtttgtt taaagactgg gaggagttgg gggaggagat tagattaaag gtctttgtac     1800

taggaggctg taggcataaa ttggtctgcg caccagcacc atgcaacttt ttcacctctg     1860

cctaatcatc tcttgttcat gtcctactgt tcaagcctcc aagctgtgcc ttgggtggct     1920

ttggggcatg gacatcgacc cttataaaga atttggagct actgtggag                 1969


<210>  3
<211>  3182
<212>  DNA
<213>  Hepatitis B virus

<400>  3
aattccacaa cctttcacca aactctgcaa gatcccagag tgagaggcct gtatttccct       60

gctggtggct ccagttcagg agcagtaaac cctgttccga ctactgcctc tcccttatcg      120

tcaatcttct cgaggattgg ggaccctgcg ctgaacatgg agaacatcac atcaggattc      180

ctaggacccc ttctcgtgtt acaggcgggg tttttcttgt tgacaagaat cctcacaata      240

ccgcagagtc tagactcgtg gtggacttct ctcaattttc tagggggaac taccgtgtgt      300

cttggccaaa attcgcagtc cccaacctcc aatcactcac caacctcctg tcctccaact      360

tgtcctggtt atcgctggat gtgtctgcgg cgttttatca tcttcctctt catcctgctg      420

ctatgcctca tcttcttgtt ggttcttctg gactatcaag gtatgttgcc cgtttgtcct      480

ctaattccag gatcctcaac caccagcacg ggaccatgcc gaacctgcat gactactgct      540

caaggaacct ctatgtatcc ctcctgttgc tgtaccaaac cttcggacgg aaattgcacc      600

tgtattccca tcccatcatc ctgggctttc ggaaaattcc tatgggagtg ggcctcagcc      660

cgtttctcct ggctcagttt actagtgcca tttgttcagt ggttcgtagg gctttccccc      720

actgtttggc tttcagttat atggatgatg tggtattggg ggccaagtct gtacagcatc      780

ttgagtccct ttttaccgct gttaccaatt ttcttttgtc tttgggtata catttaaacc      840

ctaacaaaac aaagagatgg ggttactctc tgaattttat gggttatgtc attggaagtt      900

atgggtcctt gccacaagaa cacatcatac aaaaaatcaa agaatgtttt agaaaacttc      960

ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt ttgggttttg     1020

ctgccccatt tacacaatgt ggttatcctg cgttaatgcc cttgtatgca tgtattcaat     1080

ctaagcaggc tttcactttc tcgccaactt acaaggcctt tctgtgtaaa caatacctga     1140

acctttaccc cgttgcccgg caacggccag gtctgtgcca agtgtttgct gacgcaaccc     1200

ccactggctg gggcttggtc atgggccatc agcgcgtgcg tggaaccttt tcggctcctc     1260

tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcagcagg tctggagcaa     1320

acattatcgg gactgataac tctgttgtcc tctcccgcaa atatacatcg tatccatggc     1380

tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac gtcccgtcgg     1440

cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg actctctcgt ccccttctcc     1500

gtctgccgtt ccgaccgacc acggggcgca cctctcttta cgcggactcc ccgtctgtgc     1560

cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca tggagaccac     1620

cgtgaacgcc caccgaatgt tgcccaaggt cttacataag aggactcttg gactctctgc     1680

aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag actgggagga     1740

gttgggggag gagattagat taaaggtctt tgtactagga ggctgtaggc ataaattggt     1800

ctgcgcacca gcaccatgca actttttcac ctctgcctaa tcatctcttg ttcatgtcct     1860

actgttcaag cctccaagct gtgccttggg tggctttggg gcatggacat cgacccttat     1920

aaagaatttg gagctactgt ggagttactc tcgtttttgc cttctgactt ctttccttca     1980

gtacgagatc ttctagatac cgcctcagct ctgtatcggg aagccttaga gtctcctgag     2040

cattgttcac ctcaccatac tgcactcagg caagcaattc tttgctgggg ggaactaatg     2100

actctagcta cctgggtggg tgttaatttg gaagatccag catctagaga cctagtagtc     2160

agttatgtca acactaatat gggcctaaag ttcaggcaac tcttgtggtt tcacatttct     2220

tgtctcactt ttggaagaga aaccgttata gagtatttgg tgtctttcgg agtgtggatt     2280

cgcactcctc cagcttatag accaccaaat gcccctatcc tatcaacact tccggaaact     2340

actgttgtta gacgacgagg caggtcccct agaagaagaa ctccctcgcc tcgcagacga     2400

aggtctcaat cgccgcgtcg cagaagatct caatctcggg aacctcaatg ttagtattcc     2460

ttggactcat aaggtgggga actttactgg tctttattct tctactgtac ctgtctttaa     2520

tcctcattgg aaaacaccat cttttcctaa tatacattta caccaagaca ttatcaaaaa     2580

atgtgaacag tttgtaggcc cacttacagt taatgagaaa agaagattgc aattgattat     2640

gcctgctagg ttttatccaa aggttaccaa atatttacca ttggataagg gtattaaacc     2700

ttattatcca gaacatctag ttaatcatta cttccaaact agacactatt tacacactct     2760

atggaaggcg ggtatattat ataagagaga aacaacacat agcgcctcat tttgtgggtc     2820

accatattct tgggaacaag atctacagca tggggcagaa tctttccacc agcaatcctc     2880

tgggattctt tcccgaccac cagttggatc cagccttcag agcaaacaca gcaaatccag     2940

attgggactt caatcccaac aaggacacct ggccagacgc caacaaggta ggagctggag     3000

cattcgggct gggtttcacc ccaccgcacg gaggcctttt ggggtggagc cctcaggctc     3060

agggcatact acaaactttg ccagcaaatc cgcctcctgc ctccaccaat cgccagacag     3120

gaaggcagcc taccccgctg tctccacctt tgagaaacac tcatcctcag gccatgcagt     3180

gg                                                                    3182


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  4
gaaccactga acaaa                                                        15


<210>  5
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  5
cgaaccactg aacaaa                                                       16


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  6
cgaaccactg aacaa                                                        15


<210>  7
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  7
cgaaccactg aaca                                                         14


<210>  8
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  8
cgaaccactg aac                                                          13


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  9
ccgcagtatg gatcg                                                        15


<210>  10
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  10
cgcagtatgg atc                                                          13


<210>  11
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  11
gcgtaaagag aggt                                                         14


<210>  12
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  12
cgcgtaaaga gaggt                                                        15


<210>  13
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  13
gcgtaaagag agg                                                          13


<210>  14
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  14
agaaggcaca gacgg                                                        15


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  15
gagaaggcac agacgg                                                       16


<210>  16
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  16
gaagtgcaca cgg                                                          13


<210>  17
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  17
gcgaagtgca cacgg                                                        15


<210>  18
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  18
agcgaagtgc acacgg                                                       16


<210>  19
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  19
cgaagtgcac acg                                                          13


<210>  20
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  20
agcgaagtgc acacg                                                        15


<210>  21
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  21
aagcgaagtg cacacg                                                       16


<210>  22
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  22
gaagcgaagt gcaca                                                        15


<210>  23
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  23
ggtgaagcga agtgca                                                       16


<210>  24
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  24
ggtgaagcga agtgc                                                        15


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  25
aggtgaagcg aagtgc                                                       16


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  26
aggtgaagcg aagtg                                                        15


<210>  27
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  27
aggtgaagcg aagt                                                         14


<210>  28
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  28
cagaggtgaa gcga                                                         14


<210>  29
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  29
aaaaccccgc ctgt                                                         14


<210>  30
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  30
aaaaccccgc ctg                                                          13


<210>  31
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  31
acgagtctag actct                                                        15


<210>  32
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  32
cacgagtcta gactct                                                       16


<210>  33
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  33
acgagtctag actc                                                         14


<210>  34
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  34
cacgagtcta gactc                                                        15


<210>  35
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  35
ccacgagtct agactc                                                       16


<210>  36
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  36
acgagtctag act                                                          13


<210>  37
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  37
cacgagtcta gact                                                         14


<210>  38
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  38
ccacgagtct agact                                                        15


<210>  39
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  39
accacgagtc tagact                                                       16


<210>  40
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  40
acgagtctag ac                                                           12


<210>  41
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  41
cacgagtcta gac                                                          13


<210>  42
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  42
ccacgagtct agac                                                         14


<210>  43
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  43
accacgagtc tagac                                                        15


<210>  44
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  44
caccacgagt ctagac                                                       16


<210>  45
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  45
accacgagtc taga                                                         14


<210>  46
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  46
caccacgagt ctaga                                                        15


<210>  47
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  47
ccaccacgag tctaga                                                       16


<210>  48
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  48
ccaccacgag tctag                                                        15


<210>  49
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  49
tccaccacga gtctag                                                       16


<210>  50
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  50
ccaccacgag tcta                                                         14


<210>  51
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  51
tccaccacga gtcta                                                        15


<210>  52
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  52
gtccaccacg agtcta                                                       16


<210>  53
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  53
tccaccacga gtct                                                         14


<210>  54
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  54
gtccaccacg agtct                                                        15


<210>  55
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  55
agtccaccac gagtct                                                       16


<210>  56
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  56
gtccaccacg agtc                                                         14


<210>  57
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  57
agtccaccac gagtc                                                        15


<210>  58
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  58
aagtccacca cgagtc                                                       16


<210>  59
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  59
agtccaccac gagt                                                         14


<210>  60
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  60
aagtccacca cgagt                                                        15


<210>  61
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  61
gaagtccacc acgagt                                                       16


<210>  62
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  62
aagtccacca cgag                                                         14


<210>  63
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  63
gaagtccacc acgag                                                        15


<210>  64
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  64
agaagtccac cacgag                                                       16


<210>  65
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  65
agaagtccac cacga                                                        15


<210>  66
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  66
gagaagtcca ccacga                                                       16


<210>  67
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  67
gagaagtcca ccacg                                                        15


<210>  68
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  68
agagaagtcc accacg                                                       16


<210>  69
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  69
gagagaagtc caccac                                                       16


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  70
gagagaagtc cacca                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  71
tgagagaagt ccacca                                                       16


<210>  72
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  72
gagagaagtc cacc                                                         14


<210>  73
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  73
tgagagaagt ccacc                                                        15


<210>  74
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  74
tgagagaagt ccac                                                         14


<210>  75
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  75
aaaacgccgc aga                                                          13


<210>  76
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  76
taaaacgccg caga                                                         14


<210>  77
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  77
ataaaacgcc gcaga                                                        15


<210>  78
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  78
gataaaacgc cgcaga                                                       16


<210>  79
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  79
ataaaacgcc gcag                                                         14


<210>  80
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  80
gataaaacgc cgcag                                                        15


<210>  81
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  81
tgataaaacg ccgcag                                                       16


<210>  82
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  82
ataaaacgcc gca                                                          13


<210>  83
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  83
gataaaacgc cgca                                                         14


<210>  84
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  84
tgataaaacg ccgca                                                        15


<210>  85
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  85
atgataaaac gccgca                                                       16


<210>  86
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  86
ataaaacgcc gc                                                           12


<210>  87
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  87
gataaaacgc cgc                                                          13


<210>  88
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  88
tgataaaacg ccgc                                                         14


<210>  89
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  89
atgataaaac gccgc                                                        15


<210>  90
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  90
gataaaacgc cg                                                           12


<210>  91
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  91
tgataaaacg ccg                                                          13


<210>  92
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  92
atgataaaac gccg                                                         14


<210>  93
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  93
tgataaaacg cc                                                           12


<210>  94
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  94
atgataaaac gcc                                                          13


<210>  95
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  95
atgataaaac gc                                                           12


<210>  96
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  96
tagcagcagg atg                                                          13


<210>  97
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  97
atagcagcag gatg                                                         14


<210>  98
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  98
catagcagca ggatg                                                        15


<210>  99
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  99
gcatagcagc aggatg                                                       16


<210>  100
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  100
gcatagcagc aggat                                                        15


<210>  101
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  101
ggcatagcag caggat                                                       16


<210>  102
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  102
gaggcatagc agcagg                                                       16


<210>  103
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  103
tgaggcatag cagcag                                                       16


<210>  104
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  104
tgaggcatag cagca                                                        15


<210>  105
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  105
atgaggcata gcagca                                                       16


<210>  106
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  106
tgaggcatag cagc                                                         14


<210>  107
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  107
atgaggcata gcagc                                                        15


<210>  108
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  108
gatgaggcat agcagc                                                       16


<210>  109
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  109
gatgaggcat agcag                                                        15


<210>  110
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  110
agatgaggca tagcag                                                       16


<210>  111
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  111
gatgaggcat agca                                                         14


<210>  112
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  112
agatgaggca tagca                                                        15


<210>  113
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  113
aagatgaggc atagca                                                       16


<210>  114
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  114
aagaagatga ggcata                                                       16


<210>  115
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  115
aagaagatga ggcat                                                        15


<210>  116
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  116
tgggatggga ataca                                                        15


<210>  117
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  117
atgggatggg aataca                                                       16


<210>  118
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  118
tgggatggga atac                                                         14


<210>  119
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  119
atgggatggg aatac                                                        15


<210>  120
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  120
gatgggatgg gaatac                                                       16


<210>  121
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  121
atgggatggg aata                                                         14


<210>  122
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  122
gatgggatgg gaata                                                        15


<210>  123
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  123
gatgggatgg gaat                                                         14


<210>  124
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  124
aaccactgaa caaa                                                         14


<210>  125
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  125
cgaaccactg aa                                                           12


<210>  126
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  126
gggggaaagc cct                                                          13


<210>  127
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  127
tgggggaaag ccct                                                         14


<210>  128
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  128
gcaacggggt aaagg                                                        15


<210>  129
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  129
gcaacggggt aaag                                                         14


<210>  130
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  130
gcaacggggt aaa                                                          13


<210>  131
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  131
agcaaacact tggca                                                        15


<210>  132
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  132
cagcaaacac ttggca                                                       16


<210>  133
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  133
cagcaaacac ttggc                                                        15


<210>  134
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  134
tcagcaaaca cttggc                                                       16


<210>  135
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  135
tcagcaaaca cttgg                                                        15


<210>  136
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  136
gcagtatgga tcg                                                          13


<210>  137
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  137
cgcagtatgg atcg                                                         14


<210>  138
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  138
tccgcagtat ggatcg                                                       16


<210>  139
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  139
ccgcagtatg gatc                                                         14


<210>  140
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  140
tccgcagtat ggatc                                                        15


<210>  141
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  141
cgcagtatgg at                                                           12


<210>  142
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  142
ccgcagtatg gat                                                          13


<210>  143
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  143
tccgcagtat ggat                                                         14


<210>  144
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  144
tccgcagtat gga                                                          13


<210>  145
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  145
ttccgcagta tg                                                           12


<210>  146
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  146
cgtaaagaga ggt                                                          13


<210>  147
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  147
ccgcgtaaag agaggt                                                       16


<210>  148
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  148
cgtaaagaga gg                                                           12


<210>  149
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  149
cgcgtaaaga gagg                                                         14


<210>  150
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  150
ccgcgtaaag agagg                                                        15


<210>  151
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  151
cgcgtaaaga gag                                                          13


<210>  152
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  152
ccgcgtaaag agag                                                         14


<210>  153
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  153
cgcgtaaaga ga                                                           12


<210>  154
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  154
ccgcgtaaag aga                                                          13


<210>  155
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  155
ccgcgtaaag ag                                                           12


<210>  156
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  156
ggcacagacg gggag                                                        15


<210>  157
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  157
aggcacagac ggggag                                                       16


<210>  158
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  158
ggcacagacg ggga                                                         14


<210>  159
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  159
aggcacagac gggga                                                        15


<210>  160
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  160
aaggcacaga cgggga                                                       16


<210>  161
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  161
aggcacagac gggg                                                         14


<210>  162
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  162
aaggcacaga cgggg                                                        15


<210>  163
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  163
gaaggcacag acgggg                                                       16


<210>  164
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  164
agaaggcaca gacggg                                                       16


<210>  165
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  165
gagaaggcac agacg                                                        15


<210>  166
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  166
cgaagtgcac acgg                                                         14


<210>  167
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  167
gcgaagtgca cacg                                                         14


<210>  168
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  168
gcgaagtgca cac                                                          13


<210>  169
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  169
agcgaagtgc acac                                                         14


<210>  170
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  170
aagcgaagtg cacac                                                        15


<210>  171
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  171
gaagcgaagt gcacac                                                       16


<210>  172
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  172
agcgaagtgc aca                                                          13


<210>  173
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  173
aagcgaagtg caca                                                         14


<210>  174
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  174
tgaagcgaag tgcaca                                                       16


<210>  175
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  175
aagcgaagtg cac                                                          13


<210>  176
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  176
gaagcgaagt gcac                                                         14


<210>  177
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  177
tgaagcgaag tgcac                                                        15


<210>  178
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  178
gtgaagcgaa gtgcac                                                       16


<210>  179
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  179
aagcgaagtg ca                                                           12


<210>  180
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  180
gaagcgaagt gca                                                          13


<210>  181
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  181
tgaagcgaag tgca                                                         14


<210>  182
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  182
gtgaagcgaa gtgca                                                        15


<210>  183
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  183
tgaagcgaag tgc                                                          13


<210>  184
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  184
gtgaagcgaa gtgc                                                         14


<210>  185
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  185
gtgaagcgaa gtg                                                          13


<210>  186
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  186
ggtgaagcga agtg                                                         14


<210>  187
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  187
gaggtgaagc gaagtg                                                       16


<210>  188
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  188
gtgaagcgaa gt                                                           12


<210>  189
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  189
ggtgaagcga agt                                                          13


<210>  190
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  190
gaggtgaagc gaagt                                                        15


<210>  191
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  191
agaggtgaag cgaagt                                                       16


<210>  192
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  192
agaggtgaag cgaag                                                        15


<210>  193
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  193
cagaggtgaa gcgaag                                                       16


<210>  194
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  194
agaggtgaag cgaa                                                         14


<210>  195
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  195
cagaggtgaa gcgaa                                                        15


<210>  196
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  196
gcagaggtga agcgaa                                                       16


<210>  197
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  197
gcagaggtga agcga                                                        15


<210>  198
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  198
tgcagaggtg aagcga                                                       16


<210>  199
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  199
tgcagaggtg aagcg                                                        15


<210>  200
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  200
gtgcagaggt gaagcg                                                       16


<210>  201
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  201
cgtgcagagg tgaagc                                                       16


<210>  202
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  202
cgtgcagagg tgaag                                                        15


<210>  203
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  203
acgtgcagag gtgaag                                                       16


<210>  204
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  204
cgtgcagagg tgaa                                                         14


<210>  205
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  205
acgtgcagag gtgaa                                                        15


<210>  206
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  206
cgtgcagagg tga                                                          13


<210>  207
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  207
acgtgcagag gtga                                                         14


<210>  208
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  208
cgttcacggt ggt                                                          13


<210>  209
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  209
ctcaaggtcg gtc                                                          13


<210>  210
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  210
cctcaaggtc ggt                                                          13


<210>  211
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  211
gcctcaaggt cggt                                                         14


<210>  212
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  212
acagtctttg aagta                                                        15


<210>  213
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  213
tttatgccta cag                                                          13


<210>  214
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  214
aatttatgcc taca                                                         14


<210>  215
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  215
aatttatgcc tac                                                          13


<210>  216
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  216
ccaatttatg cct                                                          13


<210>  217
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  217
gcttggaggc ttgaa                                                        15


<210>  218
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  218
agcttggagg cttgaa                                                       16


<210>  219
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  219
gcttggaggc ttga                                                         14


<210>  220
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  220
agcttggagg cttga                                                        15


<210>  221
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  221
cagcttggag gcttga                                                       16


<210>  222
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  222
gcttggaggc ttg                                                          13


<210>  223
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  223
agcttggagg cttg                                                         14


<210>  224
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  224
cagcttggag gcttg                                                        15


<210>  225
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  225
acagcttgga ggcttg                                                       16


<210>  226
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  226
cacagcttgg aggctt                                                       16


<210>  227
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  227
cacagcttgg aggct                                                        15


<210>  228
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  228
gcacagcttg gaggct                                                       16


<210>  229
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  229
gcacagcttg gaggc                                                        15


<210>  230
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  230
ggcacagctt ggaggc                                                       16


<210>  231
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  231
aggcacagct tggagg                                                       16


<210>  232
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  232
aggcacagct tggag                                                        15


<210>  233
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  233
aaggcacagc ttggag                                                       16


<210>  234
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  234
aaggcacagc ttgga                                                        15


<210>  235
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  235
caaggcacag cttgga                                                       16


<210>  236
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  236
aaggcacagc ttgg                                                         14


<210>  237
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  237
caaggcacag cttgg                                                        15


<210>  238
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  238
ccaaggcaca gcttgg                                                       16


<210>  239
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  239
caaggcacag cttg                                                         14


<210>  240
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  240
ccaaggcaca gcttg                                                        15


<210>  241
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  241
ccaaggcaca gctt                                                         14


<210>  242
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  242
tgcgaatcca cac                                                          13


<210>  243
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  243
gtgcgaatcc acac                                                         14


<210>  244
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  244
ggagttcttc ttcta                                                        15


<210>  245
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  245
gggagttctt cttcta                                                       16


<210>  246
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  246
gggagttctt cttct                                                        15


<210>  247
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  247
agggagttct tcttct                                                       16


<210>  248
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  248
agggagttct tcttc                                                        15


<210>  249
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  249
gagggagttc ttcttc                                                       16


<210>  250
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  250
agggagttct tctt                                                         14


<210>  251
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  251
gagggagttc ttctt                                                        15


<210>  252
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  252
cgagggagtt cttctt                                                       16


<210>  253
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  253
cgagggagtt cttct                                                        15


<210>  254
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  254
gcgagggagt tcttct                                                       16


<210>  255
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  255
gcgagggagt tcttc                                                        15


<210>  256
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  256
ggcgagggag ttcttc                                                       16


<210>  257
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  257
gcgagggagt tctt                                                         14


<210>  258
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  258
ggcgagggag ttctt                                                        15


<210>  259
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  259
aggcgaggga gttctt                                                       16


<210>  260
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  260
gcgagggagt tct                                                          13


<210>  261
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  261
ggcgagggag ttct                                                         14


<210>  262
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  262
aggcgaggga gttct                                                        15


<210>  263
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  263
gaggcgaggg agttct                                                       16


<210>  264
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  264
ggcgagggag ttc                                                          13


<210>  265
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  265
aggcgaggga gttc                                                         14


<210>  266
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  266
gaggcgaggg agttc                                                        15


<210>  267
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  267
cgaggcgagg gagttc                                                       16


<210>  268
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  268
aggcgaggga gtt                                                          13


<210>  269
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  269
gaggcgaggg agtt                                                         14


<210>  270
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  270
cgaggcgagg gagtt                                                        15


<210>  271
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  271
gcgaggcgag ggagtt                                                       16


<210>  272
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  272
gaggcgaggg agt                                                          13


<210>  273
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  273
cgaggcgagg gagt                                                         14


<210>  274
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  274
gcgaggcgag ggagt                                                        15


<210>  275
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  275
tgcgaggcga gggagt                                                       16


<210>  276
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  276
cgaggcgagg gag                                                          13


<210>  277
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  277
gcgaggcgag ggag                                                         14


<210>  278
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  278
tgcgaggcga gggag                                                        15


<210>  279
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  279
ctgcgaggcg agggag                                                       16


<210>  280
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  280
cgaggcgagg ga                                                           12


<210>  281
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  281
gcgaggcgag gga                                                          13


<210>  282
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  282
tgcgaggcga ggga                                                         14


<210>  283
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  283
ctgcgaggcg aggga                                                        15


<210>  284
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  284
tctgcgaggc gaggga                                                       16


<210>  285
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  285
tctgcgaggc gaggg                                                        15


<210>  286
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  286
gtctgcgagg cgaggg                                                       16


<210>  287
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  287
gttcccaaga atat                                                         14


<210>  288
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  288
tgttcccaag aatat                                                        15


<210>  289
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  289
gttcccaaga ata                                                          13


<210>  290
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  290
tgttcccaag aata                                                         14


<210>  291
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  291
ttgttcccaa gaata                                                        15


<210>  292
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  292
tgttcccaag aat                                                          13


<210>  293
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  293
ttgttcccaa gaat                                                         14


<210>  294
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  294
gaaccactga acaaa                                                        15


<210>  295
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  295
cgaaccactg aacaaa                                                       16


<210>  296
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  296
cgaaccactg aacaa                                                        15


<210>  297
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  297
cgaaccactg aaca                                                         14


<210>  298
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  298
cgaaccactg aac                                                          13


<210>  299
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  299
ccgcagtatg gatcg                                                        15


<210>  300
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  300
cgcagtatgg atc                                                          13


<210>  301
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  301
gcgtaaagag aggt                                                         14


<210>  302
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  302
cgcgtaaaga gaggt                                                        15


<210>  303
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  303
gcgtaaagag agg                                                          13


<210>  304
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  304
agaaggcaca gacgg                                                        15


<210>  305
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  305
gagaaggcac agacgg                                                       16


<210>  306
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  306
gaagtgcaca cgg                                                          13


<210>  307
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  307
gcgaagtgca cacgg                                                        15


<210>  308
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  308
agcgaagtgc acacgg                                                       16


<210>  309
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  309
cgaagtgcac acg                                                          13


<210>  310
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  310
agcgaagtgc acacg                                                        15


<210>  311
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  311
aagcgaagtg cacacg                                                       16


<210>  312
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  312
gaagcgaagt gcaca                                                        15


<210>  313
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  313
ggtgaagcga agtgca                                                       16


<210>  314
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  314
ggtgaagcga agtgc                                                        15


<210>  315
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  315
aggtgaagcg aagtgc                                                       16


<210>  316
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  316
aggtgaagcg aagtg                                                        15


<210>  317
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  317
aggtgaagcg aagt                                                         14


<210>  318
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  318
cagaggtgaa gcga                                                         14


<210>  319
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  319
aaaaccccgc ctgt                                                         14


<210>  320
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  320
aaaaccccgc ctg                                                          13


<210>  321
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  321
acgagtctag actct                                                        15


<210>  322
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  322
cacgagtcta gactct                                                       16


<210>  323
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  323
acgagtctag actc                                                         14


<210>  324
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  324
cacgagtcta gactc                                                        15


<210>  325
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  325
ccacgagtct agactc                                                       16


<210>  326
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  326
acgagtctag act                                                          13


<210>  327
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  327
cacgagtcta gact                                                         14


<210>  328
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  328
ccacgagtct agact                                                        15


<210>  329
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  329
accacgagtc tagact                                                       16


<210>  330
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  330
acgagtctag ac                                                           12


<210>  331
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  331
cacgagtcta gac                                                          13


<210>  332
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  332
ccacgagtct agac                                                         14


<210>  333
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  333
accacgagtc tagac                                                        15


<210>  334
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  334
caccacgagt ctagac                                                       16


<210>  335
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  335
accacgagtc taga                                                         14


<210>  336
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  336
caccacgagt ctaga                                                        15


<210>  337
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  337
ccaccacgag tctaga                                                       16


<210>  338
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  338
ccaccacgag tctag                                                        15


<210>  339
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  339
tccaccacga gtctag                                                       16


<210>  340
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  340
ccaccacgag tcta                                                         14


<210>  341
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  341
tccaccacga gtcta                                                        15


<210>  342
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  342
gtccaccacg agtcta                                                       16


<210>  343
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  343
tccaccacga gtct                                                         14


<210>  344
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  344
gtccaccacg agtct                                                        15


<210>  345
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  345
agtccaccac gagtct                                                       16


<210>  346
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  346
gtccaccacg agtc                                                         14


<210>  347
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  347
agtccaccac gagtc                                                        15


<210>  348
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  348
aagtccacca cgagtc                                                       16


<210>  349
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  349
agtccaccac gagt                                                         14


<210>  350
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  350
aagtccacca cgagt                                                        15


<210>  351
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  351
gaagtccacc acgagt                                                       16


<210>  352
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(14)

<400>  352
aagtccacca cgag                                                         14


<210>  353
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  353
gaagtccacc acgag                                                        15


<210>  354
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  354
agaagtccac cacgag                                                       16


<210>  355
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  355
agaagtccac cacga                                                        15


<210>  356
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  356
gagaagtcca ccacga                                                       16


<210>  357
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  357
gagaagtcca ccacg                                                        15


<210>  358
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  358
agagaagtcc accacg                                                       16


<210>  359
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  359
gagagaagtc caccac                                                       16


<210>  360
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  360
gagagaagtc cacca                                                        15


<210>  361
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  361
tgagagaagt ccacca                                                       16


<210>  362
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  362
gagagaagtc cacc                                                         14


<210>  363
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  363
tgagagaagt ccacc                                                        15


<210>  364
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  364
tgagagaagt ccac                                                         14


<210>  365
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  365
aaaacgccgc aga                                                          13


<210>  366
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  366
taaaacgccg caga                                                         14


<210>  367
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  367
ataaaacgcc gcaga                                                        15


<210>  368
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  368
gataaaacgc cgcaga                                                       16


<210>  369
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  369
ataaaacgcc gcag                                                         14


<210>  370
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  370
gataaaacgc cgcag                                                        15


<210>  371
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  371
tgataaaacg ccgcag                                                       16


<210>  372
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  372
ataaaacgcc gca                                                          13


<210>  373
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  373
gataaaacgc cgca                                                         14


<210>  374
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  374
tgataaaacg ccgca                                                        15


<210>  375
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  375
atgataaaac gccgca                                                       16


<210>  376
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  376
ataaaacgcc gc                                                           12


<210>  377
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  377
gataaaacgc cgc                                                          13


<210>  378
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  378
tgataaaacg ccgc                                                         14


<210>  379
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  379
atgataaaac gccgc                                                        15


<210>  380
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  380
gataaaacgc cg                                                           12


<210>  381
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  381
tgataaaacg ccg                                                          13


<210>  382
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  382
atgataaaac gccg                                                         14


<210>  383
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  383
tgataaaacg cc                                                           12


<210>  384
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  384
atgataaaac gcc                                                          13


<210>  385
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  385
atgataaaac gc                                                           12


<210>  386
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  386
tagcagcagg atg                                                          13


<210>  387
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  387
atagcagcag gatg                                                         14


<210>  388
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  388
catagcagca ggatg                                                        15


<210>  389
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  389
gcatagcagc aggatg                                                       16


<210>  390
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  390
gcatagcagc aggat                                                        15


<210>  391
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  391
ggcatagcag caggat                                                       16


<210>  392
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  392
gaggcatagc agcagg                                                       16


<210>  393
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  393
tgaggcatag cagcag                                                       16


<210>  394
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  394
tgaggcatag cagca                                                        15


<210>  395
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  395
atgaggcata gcagca                                                       16


<210>  396
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  396
tgaggcatag cagc                                                         14


<210>  397
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  397
atgaggcata gcagc                                                        15


<210>  398
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  398
gatgaggcat agcagc                                                       16


<210>  399
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  399
gatgaggcat agcag                                                        15


<210>  400
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  400
agatgaggca tagcag                                                       16


<210>  401
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  401
gatgaggcat agca                                                         14


<210>  402
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  402
agatgaggca tagca                                                        15


<210>  403
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  403
aagatgaggc atagca                                                       16


<210>  404
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  404
aagaagatga ggcata                                                       16


<210>  405
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  405
aagaagatga ggcat                                                        15


<210>  406
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  406
tgggatggga ataca                                                        15


<210>  407
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  407
atgggatggg aataca                                                       16


<210>  408
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  408
tgggatggga atac                                                         14


<210>  409
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  409
atgggatggg aatac                                                        15


<210>  410
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  410
gatgggatgg gaatac                                                       16


<210>  411
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  411
atgggatggg aata                                                         14


<210>  412
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  412
gatgggatgg gaata                                                        15


<210>  413
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  413
gatgggatgg gaat                                                         14


<210>  414
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  414
aaccactgaa caaa                                                         14


<210>  415
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  415
cgaaccactg aa                                                           12


<210>  416
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  416
gggggaaagc cct                                                          13


<210>  417
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  417
tgggggaaag ccct                                                         14


<210>  418
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  418
gcaacggggt aaagg                                                        15


<210>  419
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  419
gcaacggggt aaag                                                         14


<210>  420
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  420
gcaacggggt aaa                                                          13


<210>  421
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  421
agcaaacact tggca                                                        15


<210>  422
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  422
cagcaaacac ttggca                                                       16


<210>  423
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  423
cagcaaacac ttggc                                                        15


<210>  424
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  424
tcagcaaaca cttggc                                                       16


<210>  425
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  425
tcagcaaaca cttgg                                                        15


<210>  426
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  426
gcagtatgga tcg                                                          13


<210>  427
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  427
cgcagtatgg atcg                                                         14


<210>  428
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  428
tccgcagtat ggatcg                                                       16


<210>  429
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  429
ccgcagtatg gatc                                                         14


<210>  430
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  430
tccgcagtat ggatc                                                        15


<210>  431
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  431
cgcagtatgg at                                                           12


<210>  432
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  432
ccgcagtatg gat                                                          13


<210>  433
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  433
tccgcagtat ggat                                                         14


<210>  434
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  434
tccgcagtat gga                                                          13


<210>  435
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  435
ttccgcagta tg                                                           12


<210>  436
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  436
cgtaaagaga ggt                                                          13


<210>  437
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  437
ccgcgtaaag agaggt                                                       16


<210>  438
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  438
cgtaaagaga gg                                                           12


<210>  439
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  439
cgcgtaaaga gagg                                                         14


<210>  440
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  440
ccgcgtaaag agagg                                                        15


<210>  441
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  441
cgcgtaaaga gag                                                          13


<210>  442
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  442
ccgcgtaaag agag                                                         14


<210>  443
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (3)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  443
cgcgtaaaga ga                                                           12


<210>  444
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  444
ccgcgtaaag aga                                                          13


<210>  445
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  445
ccgcgtaaag ag                                                           12


<210>  446
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  446
ggcacagacg gggag                                                        15


<210>  447
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  447
aggcacagac ggggag                                                       16


<210>  448
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  448
ggcacagacg ggga                                                         14


<210>  449
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  449
aggcacagac gggga                                                        15


<210>  450
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  450
aaggcacaga cgggga                                                       16


<210>  451
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  451
aggcacagac gggg                                                         14


<210>  452
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  452
aaggcacaga cgggg                                                        15


<210>  453
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  453
gaaggcacag acgggg                                                       16


<210>  454
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  454
agaaggcaca gacggg                                                       16


<210>  455
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  455
gagaaggcac agacg                                                        15


<210>  456
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  456
cgaagtgcac acgg                                                         14


<210>  457
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  457
gcgaagtgca cacg                                                         14


<210>  458
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  458
gcgaagtgca cac                                                          13


<210>  459
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  459
agcgaagtgc acac                                                         14


<210>  460
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  460
aagcgaagtg cacac                                                        15


<210>  461
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  461
gaagcgaagt gcacac                                                       16


<210>  462
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  462
agcgaagtgc aca                                                          13


<210>  463
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  463
aagcgaagtg caca                                                         14


<210>  464
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  464
tgaagcgaag tgcaca                                                       16


<210>  465
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  465
aagcgaagtg cac                                                          13


<210>  466
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  466
gaagcgaagt gcac                                                         14


<210>  467
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  467
tgaagcgaag tgcac                                                        15


<210>  468
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  468
gtgaagcgaa gtgcac                                                       16


<210>  469
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  469
aagcgaagtg ca                                                           12


<210>  470
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  470
gaagcgaagt gca                                                          13


<210>  471
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  471
tgaagcgaag tgca                                                         14


<210>  472
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  472
gtgaagcgaa gtgca                                                        15


<210>  473
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  473
tgaagcgaag tgc                                                          13


<210>  474
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  474
gtgaagcgaa gtgc                                                         14


<210>  475
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  475
gtgaagcgaa gtg                                                          13


<210>  476
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  476
ggtgaagcga agtg                                                         14


<210>  477
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  477
gaggtgaagc gaagtg                                                       16


<210>  478
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  478
gtgaagcgaa gt                                                           12


<210>  479
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  479
ggtgaagcga agt                                                          13


<210>  480
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  480
gaggtgaagc gaagt                                                        15


<210>  481
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  481
agaggtgaag cgaagt                                                       16


<210>  482
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  482
agaggtgaag cgaag                                                        15


<210>  483
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  483
cagaggtgaa gcgaag                                                       16


<210>  484
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  484
agaggtgaag cgaa                                                         14


<210>  485
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (12)..(12)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  485
cagaggtgaa gcgaa                                                        15


<210>  486
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  486
gcagaggtga agcgaa                                                       16


<210>  487
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  487
gcagaggtga agcga                                                        15


<210>  488
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  488
tgcagaggtg aagcga                                                       16


<210>  489
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  489
tgcagaggtg aagcg                                                        15


<210>  490
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  490
gtgcagaggt gaagcg                                                       16


<210>  491
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  491
cgtgcagagg tgaagc                                                       16


<210>  492
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  492
cgtgcagagg tgaag                                                        15


<210>  493
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  493
acgtgcagag gtgaag                                                       16


<210>  494
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  494
cgtgcagagg tgaa                                                         14


<210>  495
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  495
acgtgcagag gtgaa                                                        15


<210>  496
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  496
cgtgcagagg tga                                                          13


<210>  497
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  497
acgtgcagag gtga                                                         14


<210>  498
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  498
cgttcacggt ggt                                                          13


<210>  499
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  499
ctcaaggtcg gtc                                                          13


<210>  500
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  500
cctcaaggtc ggt                                                          13


<210>  501
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  501
gcctcaaggt cggt                                                         14


<210>  502
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  502
acagtctttg aagta                                                        15


<210>  503
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  503
tttatgccta cag                                                          13


<210>  504
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  504
aatttatgcc taca                                                         14


<210>  505
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  505
aatttatgcc tac                                                          13


<210>  506
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  506
ccaatttatg cct                                                          13


<210>  507
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  507
gcttggaggc ttgaa                                                        15


<210>  508
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  508
agcttggagg cttgaa                                                       16


<210>  509
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  509
gcttggaggc ttga                                                         14


<210>  510
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  510
agcttggagg cttga                                                        15


<210>  511
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  511
cagcttggag gcttga                                                       16


<210>  512
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  512
gcttggaggc ttg                                                          13


<210>  513
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  513
agcttggagg cttg                                                         14


<210>  514
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  514
cagcttggag gcttg                                                        15


<210>  515
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  515
acagcttgga ggcttg                                                       16


<210>  516
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  516
cacagcttgg aggctt                                                       16


<210>  517
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  517
cacagcttgg aggct                                                        15


<210>  518
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  518
gcacagcttg gaggct                                                       16


<210>  519
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  519
gcacagcttg gaggc                                                        15


<210>  520
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  520
ggcacagctt ggaggc                                                       16


<210>  521
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  521
aggcacagct tggagg                                                       16


<210>  522
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  522
aggcacagct tggag                                                        15


<210>  523
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  523
aaggcacagc ttggag                                                       16


<210>  524
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  524
aaggcacagc ttgga                                                        15


<210>  525
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  525
caaggcacag cttgga                                                       16


<210>  526
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  526
aaggcacagc ttgg                                                         14


<210>  527
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  527
caaggcacag cttgg                                                        15


<210>  528
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  528
ccaaggcaca gcttgg                                                       16


<210>  529
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  529
caaggcacag cttg                                                         14


<210>  530
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  530
ccaaggcaca gcttg                                                        15


<210>  531
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  531
ccaaggcaca gctt                                                         14


<210>  532
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  532
tgcgaatcca cac                                                          13


<210>  533
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  533
gtgcgaatcc acac                                                         14


<210>  534
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  534
ggagttcttc ttcta                                                        15


<210>  535
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  535
gggagttctt cttcta                                                       16


<210>  536
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  536
gggagttctt cttct                                                        15


<210>  537
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  537
agggagttct tcttct                                                       16


<210>  538
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  538
agggagttct tcttc                                                        15


<210>  539
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  539
gagggagttc ttcttc                                                       16


<210>  540
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  540
agggagttct tctt                                                         14


<210>  541
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  541
gagggagttc ttctt                                                        15


<210>  542
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  542
cgagggagtt cttctt                                                       16


<210>  543
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  543
cgagggagtt cttct                                                        15


<210>  544
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  544
gcgagggagt tcttct                                                       16


<210>  545
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  545
gcgagggagt tcttc                                                        15


<210>  546
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  546
ggcgagggag ttcttc                                                       16


<210>  547
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  547
gcgagggagt tctt                                                         14


<210>  548
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  548
ggcgagggag ttctt                                                        15


<210>  549
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  549
aggcgaggga gttctt                                                       16


<210>  550
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  550
gcgagggagt tct                                                          13


<210>  551
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  551
ggcgagggag ttct                                                         14


<210>  552
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  552
aggcgaggga gttct                                                        15


<210>  553
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  553
gaggcgaggg agttct                                                       16


<210>  554
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  554
ggcgagggag ttc                                                          13


<210>  555
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  555
aggcgaggga gttc                                                         14


<210>  556
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  556
gaggcgaggg agttc                                                        15


<210>  557
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  557
cgaggcgagg gagttc                                                       16


<210>  558
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  558
aggcgaggga gtt                                                          13


<210>  559
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  559
gaggcgaggg agtt                                                         14


<210>  560
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  560
cgaggcgagg gagtt                                                        15


<210>  561
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  561
gcgaggcgag ggagtt                                                       16


<210>  562
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  562
gaggcgaggg agt                                                          13


<210>  563
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  563
cgaggcgagg gagt                                                         14


<210>  564
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  564
gcgaggcgag ggagt                                                        15


<210>  565
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  565
tgcgaggcga gggagt                                                       16


<210>  566
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  566
cgaggcgagg gag                                                          13


<210>  567
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  567
gcgaggcgag ggag                                                         14


<210>  568
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  568
tgcgaggcga gggag                                                        15


<210>  569
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  569
ctgcgaggcg agggag                                                       16


<210>  570
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(12)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (11)..(12)

<400>  570
cgaggcgagg ga                                                           12


<210>  571
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  571
gcgaggcgag gga                                                          13


<210>  572
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  572
tgcgaggcga ggga                                                         14


<210>  573
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  573
ctgcgaggcg aggga                                                        15


<210>  574
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  574
tctgcgaggc gaggga                                                       16


<210>  575
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  5-methyl c
<222>  (10)..(10)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  575
tctgcgaggc gaggg                                                        15


<210>  576
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  576
gtctgcgagg cgaggg                                                       16


<210>  577
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  577
gttcccaaga atat                                                         14


<210>  578
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  578
tgttcccaag aatat                                                        15


<210>  579
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  579
gttcccaaga ata                                                          13


<210>  580
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  580
tgttcccaag aata                                                         14


<210>  581
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  581
ttgttcccaa gaata                                                        15


<210>  582
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  582
tgttcccaag aat                                                          13


<210>  583
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  583
ttgttcccaa gaat                                                         14


<210>  584
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  584
gaggcatagc agcagg                                                       16


<210>  585
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  585
gaaccactga acaaa                                                        15


<210>  586
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  586
gaaccactga acaaa                                                        15


<210>  587
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  587
cgaaccactg aacaaa                                                       16


<210>  588
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  588
cgaaccactg aacaaa                                                       16


<210>  589
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  589
cgaaccactg aacaaa                                                       16


<210>  590
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  590
cgaaccactg aacaaa                                                       16


<210>  591
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  591
cgaaccactg aacaaa                                                       16


<210>  592
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  592
cgaaccactg aacaa                                                        15


<210>  593
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  593
cgaaccactg aacaa                                                        15


<210>  594
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  594
cgaaccactg aacaa                                                        15


<210>  595
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  595
cgaaccactg aaca                                                         14


<210>  596
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(14)

<400>  596
cgaaccactg aaca                                                         14


<210>  597
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  597
cgaaccactg aaca                                                         14


<210>  598
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  598
cgaaccactg aaca                                                         14


<210>  599
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  599
cgaaccactg aac                                                          13


<210>  600
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  600
cgaaccactg aac                                                          13


<210>  601
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  601
ccgcagtatg gatcg                                                        15


<210>  602
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  602
ccgcagtatg gatcg                                                        15


<210>  603
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  603
ccgcagtatg gatcg                                                        15


<210>  604
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  604
ccgcagtatg gatcg                                                        15


<210>  605
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  605
cgcagtatgg atc                                                          13


<210>  606
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  606
cgcagtatgg atc                                                          13


<210>  607
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  607
cgcagtatgg atc                                                          13


<210>  608
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (10)..(13)

<400>  608
cgcagtatgg atc                                                          13


<210>  609
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(14)

<400>  609
gcgtaaagag aggt                                                         14


<210>  610
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  610
gcgtaaagag aggt                                                         14


<210>  611
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  611
gcgtaaagag aggt                                                         14


<210>  612
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  612
gcgtaaagag aggt                                                         14


<210>  613
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  613
cgcgtaaaga gaggt                                                        15


<210>  614
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  614
cgcgtaaaga gaggt                                                        15


<210>  615
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  615
cgcgtaaaga gaggt                                                        15


<210>  616
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  616
cgcgtaaaga gaggt                                                        15


<210>  617
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  617
gcgtaaagag agg                                                          13


<210>  618
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  618
gcgtaaagag agg                                                          13


<210>  619
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (10)..(13)

<400>  619
gcgtaaagag agg                                                          13


<210>  620
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(13)

<400>  620
gcgtaaagag agg                                                          13


<210>  621
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  621
agaaggcaca gacgg                                                        15


<210>  622
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  622
agaaggcaca gacgg                                                        15


<210>  623
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  623
agaaggcaca gacgg                                                        15


<210>  624
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  624
gagaaggcac agacgg                                                       16


<210>  625
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  625
gagaaggcac agacgg                                                       16


<210>  626
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  626
gagaaggcac agacgg                                                       16


<210>  627
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  627
gaagtgcaca cgg                                                          13


<210>  628
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  628
gaagtgcaca cgg                                                          13


<210>  629
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  629
gaagtgcaca cgg                                                          13


<210>  630
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (10)..(13)

<400>  630
gaagtgcaca cgg                                                          13


<210>  631
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  631
gcgaagtgca cacgg                                                        15


<210>  632
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  632
gcgaagtgca cacgg                                                        15


<210>  633
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  633
gcgaagtgca cacgg                                                        15


<210>  634
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  634
gcgaagtgca cacgg                                                        15


<210>  635
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  635
agcgaagtgc acacgg                                                       16


<210>  636
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (3)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  636
agcgaagtgc acacgg                                                       16


<210>  637
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (3)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  637
agcgaagtgc acacgg                                                       16


<210>  638
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  638
agcgaagtgc acacgg                                                       16


<210>  639
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (10)..(13)

<400>  639
cgaagtgcac acg                                                          13


<210>  640
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  640
cgaagtgcac acg                                                          13


<210>  641
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(13)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(13)

<400>  641
cgaagtgcac acg                                                          13


<210>  642
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  642
agcgaagtgc acacg                                                        15


<210>  643
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  643
agcgaagtgc acacg                                                        15


<210>  644
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  644
agcgaagtgc acacg                                                        15


<210>  645
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (3)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  645
agcgaagtgc acacg                                                        15


<210>  646
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  646
aagcgaagtg cacacg                                                       16


<210>  647
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  647
aagcgaagtg cacacg                                                       16


<210>  648
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  648
aagcgaagtg cacacg                                                       16


<210>  649
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  649
aagcgaagtg cacacg                                                       16


<210>  650
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  650
aagcgaagtg cacacg                                                       16


<210>  651
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  651
gaagcgaagt gcaca                                                        15


<210>  652
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  652
gaagcgaagt gcaca                                                        15


<210>  653
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  653
gaagcgaagt gcaca                                                        15


<210>  654
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  654
gaagcgaagt gcaca                                                        15


<210>  655
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  655
ggtgaagcga agtgca                                                       16


<210>  656
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  656
ggtgaagcga agtgca                                                       16


<210>  657
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  657
ggtgaagcga agtgca                                                       16


<210>  658
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  658
ggtgaagcga agtgca                                                       16


<210>  659
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  659
ggtgaagcga agtgc                                                        15


<210>  660
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  660
ggtgaagcga agtgc                                                        15


<210>  661
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  661
ggtgaagcga agtgc                                                        15


<210>  662
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  662
ggtgaagcga agtgc                                                        15


<210>  663
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  663
aggtgaagcg aagtgc                                                       16


<210>  664
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  664
aggtgaagcg aagtgc                                                       16


<210>  665
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  665
aggtgaagcg aagtgc                                                       16


<210>  666
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  666
aggtgaagcg aagtgc                                                       16


<210>  667
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  667
aggtgaagcg aagtg                                                        15


<210>  668
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  668
aggtgaagcg aagtg                                                        15


<210>  669
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  669
aggtgaagcg aagtg                                                        15


<210>  670
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  670
aggtgaagcg aagtg                                                        15


<210>  671
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (13)..(14)

<400>  671
aggtgaagcg aagt                                                         14


<210>  672
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  672
aggtgaagcg aagt                                                         14


<210>  673
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  673
aggtgaagcg aagt                                                         14


<210>  674
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (9)..(9)

<220>
<221>  LNA nucleosides
<222>  (12)..(14)

<400>  674
aggtgaagcg aagt                                                         14


<210>  675
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(14)

<400>  675
cagaggtgaa gcga                                                         14


<210>  676
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  676
cagaggtgaa gcga                                                         14


<210>  677
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(14)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (11)..(14)

<400>  677
cagaggtgaa gcga                                                         14


<210>  678
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  678
tagtaaactg agcca                                                        15


<210>  679
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  679
tagtaaactg agcca                                                        15


<210>  680
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  680
tagtaaactg agcca                                                        15


<210>  681
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  681
tagtaaactg agcca                                                        15


<210>  682
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  682
tagtaaactg agcca                                                        15


<210>  683
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  683
ctagtaaact gagcca                                                       16


<210>  684
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  684
ctagtaaact gagcca                                                       16


<210>  685
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  685
ctagtaaact gagcca                                                       16


<210>  686
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  686
ctagtaaact gagcc                                                        15


<210>  687
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  687
ctagtaaact gagcc                                                        15


<210>  688
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  688
ctagtaaact gagcc                                                        15


<210>  689
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  689
ctagtaaact gagcc                                                        15


<210>  690
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  690
ctagtaaact gagcc                                                        15


<210>  691
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  691
gcactagtaa actga                                                        15


<210>  692
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  692
gcactagtaa actga                                                        15


<210>  693
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  693
gcactagtaa actga                                                        15


<210>  694
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  694
gcactagtaa actga                                                        15


<210>  695
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  695
gcactagtaa actga                                                        15


<210>  696
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  696
ggcactagta aactga                                                       16


<210>  697
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  697
ggcactagta aactga                                                       16


<210>  698
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  698
ggcactagta aactga                                                       16


<210>  699
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  699
caacggggta aaggt                                                        15


<210>  700
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  700
caacggggta aaggt                                                        15


<210>  701
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  701
caacggggta aaggt                                                        15


<210>  702
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  702
caacggggta aaggt                                                        15


<210>  703
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  703
caacggggta aaggt                                                        15


<210>  704
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  704
cagtatggat cggca                                                        15


<210>  705
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  705
cagtatggat cggca                                                        15


<210>  706
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  706
cagtatggat cggca                                                        15


<210>  707
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  707
cagtatggat cggca                                                        15


<210>  708
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  708
ttccgcagta tggatc                                                       16


<210>  709
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  709
ttccgcagta tggatc                                                       16


<210>  710
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  710
ttccgcagta tggatc                                                       16


<210>  711
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  711
ttccgcagta tggatc                                                       16


<210>  712
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  712
ttccgcagta tggatc                                                       16


<210>  713
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  713
ttccgcagta tggat                                                        15


<210>  714
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  714
ttccgcagta tggat                                                        15


<210>  715
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  715
ttccgcagta tggat                                                        15


<210>  716
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (4)..(4)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  716
ttccgcagta tggat                                                        15


<210>  717
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  717
ttccgcagta tggat                                                        15


<210>  718
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  718
gttccgcagt atggat                                                       16


<210>  719
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  719
gttccgcagt atggat                                                       16


<210>  720
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  720
gttccgcagt atggat                                                       16


<210>  721
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  721
gttccgcagt atgga                                                        15


<210>  722
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  722
gttccgcagt atgga                                                        15


<210>  723
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  723
gttccgcagt atgga                                                        15


<210>  724
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (5)..(5)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  724
gttccgcagt atgga                                                        15


<210>  725
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  725
agttccgcag tatgga                                                       16


<210>  726
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  726
agttccgcag tatgga                                                       16


<210>  727
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  727
agttccgcag tatgga                                                       16


<210>  728
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  728
agttccgcag tatgga                                                       16


<210>  729
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  729
agttccgcag tatgga                                                       16


<210>  730
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  730
agttccgcag tatgg                                                        15


<210>  731
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  731
agttccgcag tatgg                                                        15


<210>  732
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  732
agttccgcag tatgg                                                        15


<210>  733
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (6)..(6)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  733
agttccgcag tatgg                                                        15


<210>  734
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  734
gagttccgca gtatgg                                                       16


<210>  735
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  735
gagttccgca gtatgg                                                       16


<210>  736
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  736
gagttccgca gtatgg                                                       16


<210>  737
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  737
gagttccgca gtatg                                                        15


<210>  738
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  738
gagttccgca gtatg                                                        15


<210>  739
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  739
gagttccgca gtatg                                                        15


<210>  740
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (7)..(7)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  740
gagttccgca gtatg                                                        15


<210>  741
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  741
ggagttccgc agtatg                                                       16


<210>  742
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  742
ggagttccgc agtatg                                                       16


<210>  743
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  743
ggagttccgc agtatg                                                       16


<210>  744
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (8)..(8)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  744
ggagttccgc agtatg                                                       16


<210>  745
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  745
taaagagagg tgcgcc                                                       16


<210>  746
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  746
taaagagagg tgcgcc                                                       16


<210>  747
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  747
taaagagagg tgcgcc                                                       16


<210>  748
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  748
taaagagagg tgcgcc                                                       16


<210>  749
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  5-methyl c
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  749
taaagagagg tgcgcc                                                       16


<210>  750
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  750
taaagagagg tgcgc                                                        15


<210>  751
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  751
taaagagagg tgcgc                                                        15


<210>  752
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  752
taaagagagg tgcgc                                                        15


<210>  753
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  753
taaagagagg tgcgc                                                        15


<210>  754
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  754
gtaaagagag gtgcgc                                                       16


<210>  755
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  755
gtaaagagag gtgcgc                                                       16


<210>  756
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  756
gtaaagagag gtgcg                                                        15


<210>  757
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  757
gtaaagagag gtgcg                                                        15


<210>  758
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  758
gtaaagagag gtgcg                                                        15


<210>  759
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  759
gtaaagagag gtgcg                                                        15


<210>  760
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  760
cgtaaagaga ggtgcg                                                       16


<210>  761
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  761
cgtaaagaga ggtgcg                                                       16


<210>  762
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  762
cgtaaagaga ggtgcg                                                       16


<210>  763
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  763
cgtaaagaga ggtgcg                                                       16


<210>  764
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  764
cgtaaagaga ggtgc                                                        15


<210>  765
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  765
cgtaaagaga ggtgc                                                        15


<210>  766
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  766
cgtaaagaga ggtgc                                                        15


<210>  767
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  767
cgtaaagaga ggtgc                                                        15


<210>  768
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  768
cgtaaagaga ggtgc                                                        15


<210>  769
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  769
gcgtaaagag aggtgc                                                       16


<210>  770
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  770
gcgtaaagag aggtgc                                                       16


<210>  771
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  771
gcgtaaagag aggtgc                                                       16


<210>  772
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  772
gcgtaaagag aggtgc                                                       16


<210>  773
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  773
gcgtaaagag aggtg                                                        15


<210>  774
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  774
gcgtaaagag aggtg                                                        15


<210>  775
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  775
gcgtaaagag aggtg                                                        15


<210>  776
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (12)..(15)

<400>  776
gcgtaaagag aggtg                                                        15


<210>  777
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  777
gcgtaaagag aggtg                                                        15


<210>  778
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  778
cgcgtaaaga gaggtg                                                       16


<210>  779
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  5-methyl c
<222>  (1)..(1)

<220>
<221>  5-methyl c
<222>  (3)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  779
cgcgtaaaga gaggtg                                                       16


<210>  780
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  780
cgcgtaaaga gaggtg                                                       16


<210>  781
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  781
cgcgtaaaga gaggtg                                                       16


<210>  782
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  782
cgcgtaaaga gaggtg                                                       16


<210>  783
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  783
tgagaaggca cagacg                                                       16


<210>  784
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  784
tgagaaggca cagacg                                                       16


<210>  785
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (15)..(16)

<400>  785
tgagaaggca cagacg                                                       16


<210>  786
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  786
tgagaaggca cagacg                                                       16


<210>  787
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  787
tgagaaggca cagacg                                                       16


<210>  788
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  788
gcctcaaggt cggtc                                                        15


<210>  789
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  789
gcctcaaggt cggtc                                                        15


<210>  790
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  5-methyl c
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  790
gcctcaaggt cggtc                                                        15


<210>  791
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  791
atgcctacag cctcc                                                        15


<210>  792
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  792
atgcctacag cctcc                                                        15


<210>  793
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(15)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  793
atgcctacag cctcc                                                        15


<210>  794
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  794
accaatttat gcctac                                                       16


<210>  795
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  795
accaatttat gcctac                                                       16


<210>  796
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(4)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  796
accaatttat gcctac                                                       16


<210>  797
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  797
accaatttat gcctac                                                       16


<210>  798
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  phosphorothiate Internucleoside linkages
<222>  (1)..(16)

<220>
<221>  LNA nucleosides
<222>  (1)..(2)

<220>
<221>  LNA nucleosides
<222>  (13)..(16)

<400>  798
accaatttat gcctac                                                       16


<210>  799
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides
<222>  (15)..(17)

<400>  799
cagaaccact gaacaaa                                                      17


<210>  800
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(18)

<220>
<221>  LNA nucleosides
<222>  (16)..(18)

<400>  800
cacgaaccac tgaacaaa                                                     18


<210>  801
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  801
cacgaaccac tgaacaa                                                      17


<210>  802
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  802
caccgcagta tggatcg                                                      17


<210>  803
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides
<222>  (15)..(17)

<400>  803
cacgcgtaaa gagaggt                                                      17


<210>  804
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  804
caagaaggca cagacgg                                                      17


<210>  805
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(18)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (16)..(18)

<400>  805
cagagaaggc acagacgg                                                     18


<210>  806
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  806
cagcgaagtg cacacgg                                                      17


<210>  807
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(18)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (16)..(18)

<400>  807
caagcgaagt gcacacgg                                                     18


<210>  808
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  808
caagcgaagt gcacacg                                                      17


<210>  809
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(18)

<220>
<221>  5-methyl C
<222>  (11)..(11)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (16)..(18)

<400>  809
caaggtgaag cgaagtgc                                                     18


<210>  810
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  5-methyl C
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (15)..(17)

<400>  810
caaggtgaag cgaagtg                                                      17


<210>  811
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(16)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (14)..(16)

<400>  811
cacgaaccac tgaaca                                                       16


<210>  812
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (14)..(15)

<400>  812
cacgaaccac tgaac                                                        15


<210>  813
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (14)..(15)

<400>  813
cacgcagtat ggatc                                                        15


<210>  814
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(16)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  814
cagcgtaaag agaggt                                                       16


<210>  815
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  815
cagcgtaaag agagg                                                        15


<210>  816
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  5-methyl C
<222>  (13)..(13)

<220>
<221>  LNA nucleosides
<222>  (14)..(15)

<400>  816
cagaagtgca cacgg                                                        15


<210>  817
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (14)..(15)

<400>  817
cacgaagtgc acacg                                                        15


<210>  818
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(16)

<220>
<221>  5-methyl C
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(16)

<400>  818
caaggtgaag cgaagt                                                       16


<210>  819
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (14)..(17)

<400>  819
cagaaccact gaacaaa                                                      17


<210>  820
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(6)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(18)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (16)..(18)

<400>  820
cacgaaccac tgaacaaa                                                     18


<210>  821
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (13)..(15)

<400>  821
cagaagtgca cacgg                                                        15


<210>  822
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (15)..(17)

<400>  822
catagtaaac tgagcca                                                      17


<210>  823
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (13)..(15)

<400>  823
cacgaaccac tgaac                                                        15


<210>  824
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(16)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (13)..(16)

<400>  824
cacgaaccac tgaaca                                                       16


<210>  825
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides, LNA C are 5-methyl C
<222>  (3)..(5)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(15)

<220>
<221>  LNA nucleosides
<222>  (13)..(15)

<400>  825
cagcgtaaag agagg                                                        15


<210>  826
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide GalNAc conjugate


<220>
<221>  GalNAc2-C6
<222>  (1)..(1)

<220>
<221>  phosphodiester lnternucleoside linkages
<222>  (1)..(3)

<220>
<221>  LNA nucleosides
<222>  (3)..(4)

<220>
<221>  phosphorothioate lnternucleoside linkages
<222>  (4)..(17)

<220>
<221>  5-methyl C
<222>  (11)..(11)

<220>
<221>  LNA nucleosides
<222>  (14)..(17)

<400>  826
caaggtgaag cgaagtg                                                      17


<210>  827
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  827
acggggcgca cctctcttta cgcg                                              24


<210>  828
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  828
cgtgtgcact tcgcttcacc tc                                                22


<210>  829
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  829
ccgtctgtgc cttctc                                                       16


<210>  830
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  830
cgatccatac tgcgg                                                        15


<210>  831
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  831
tggctcagtt tacta                                                        15


<210>  832
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  832
ccgcagtatg gatcg                                                        15


<210>  833
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide target sequence

<400>  833
ctagtgccat ttgtt                                                        15


<210>  834
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  834
tagtaaactg agcca                                                        15


<210>  835
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  835
ctagtaaact gagcca                                                       16


<210>  836
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  836
ctagtaaact gagcc                                                        15


<210>  837
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  837
gcactagtaa actga                                                        15


<210>  838
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  838
ggcactagta aactga                                                       16


<210>  839
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  839
caacggggta aaggt                                                        15


<210>  840
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  840
cagtatggat cggca                                                        15


<210>  841
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  841
ttccgcagta tggatc                                                       16


<210>  842
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  842
ttccgcagta tggat                                                        15


<210>  843
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  843
gttccgcagt atggat                                                       16


<210>  844
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  844
gttccgcagt atgga                                                        15


<210>  845
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  845
agttccgcag tatgga                                                       16


<210>  846
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  846
agttccgcag tatgg                                                        15


<210>  847
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  847
gagttccgca gtatgg                                                       16


<210>  848
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  848
gagttccgca gtatg                                                        15


<210>  849
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  849
ggagttccgc agtatg                                                       16


<210>  850
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  850
taaagagagg tgcgcc                                                       16


<210>  851
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  851
taaagagagg tgcgc                                                        15


<210>  852
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  852
gtaaagagag gtgcgc                                                       16


<210>  853
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  853
gtaaagagag gtgcg                                                        15


<210>  854
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  854
cgtaaagaga ggtgcg                                                       16


<210>  855
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  855
cgtaaagaga ggtgc                                                        15


<210>  856
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  856
gcgtaaagag aggtgc                                                       16


<210>  857
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  857
gcgtaaagag aggtg                                                        15


<210>  858
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  858
cgcgtaaaga gaggtg                                                       16


<210>  859
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  859
tgagaaggca cagacg                                                       16


<210>  860
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  860
gcctcaaggt cggtc                                                        15


<210>  861
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  861
atgcctacag cctcc                                                        15


<210>  862
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence motif

<400>  862
accaatttat gcctac                                                       16


			RECTIFIED SHEET (RULE91) ISA/EP